Share the Science: HSC Self-Renewal, Targeting M6A RNA Pathway to Expand Cord Blood Stem Cells
Save the Cord Foundation and WellSky are proud to welcome Linheng Li, PhD from the University of Kansas Cancer Center and the Stowers Institute for Medical Research, as our featured speaker for our next edition of Share the Science on June 18th, 2020. Join us to hear Dr. Li present his research on RNA modification to promote self-renewal of HSCs, resulting in HSC expansion. Recording now available, register and watch it here.
Share the Science is a free webinar series focused on the cord blood industry and the latest research in this field. As always, we invite both health professionals and the general public to join us for this unique online educational series. Learn more about this exciting educational series here.
Join us on June 18th, 2020 to discover how hematopoietic stem cells (HSCs) are regulated, and the ways this understanding can facilitate new strategies to manage hematopoietic diseases. Linheng Li, Ph.D. will discuss his work in RNA modification to promote self-renewal of HSCs, resulting in HSC expansion.
Dr. Li will examine the key concepts around this research, including:
These insights may lead to breakthroughs in the treatment of certain leukemias, lymphomas, and myelomas.
The transplantation of human hematopoietic stem cells isolated from bone marrow is used in the treatment of anemia, immune deficiencies, and other diseases, including cancer. However, since bone marrow transplants require a suitable donor-recipient tissue match, close to one in three patients who could benefit from stem cell transplant—and as many as ninety- five percent of nonwhite patients—never find a suitable match.
Hematopoietic stem cells isolated from umbilical cord blood could be a good alternative source. Readily available and immunologically immature, they allow the donor-recipient match to be less than perfect without the risk of immune rejection by the transplantee. Unfortunately, their therapeutic use is limited since umbilical cord blood contains only about one-tenth of the stem cells found in bone marrow. (Source: Stowers Institute for Medical Research)
"Being able to tap into stem cells’ inherent potential for self-renewal could turn limited sources of hematopoietic stem cells such as umbilical cord blood into a readily available stem source with significant clinical impact,” says Li, while cautioning that his team’s findings still have a gap between genetic-blockade and small molecule inhibition of the M6A pathway in order to be applied the method in human cells.
For more information on Dr. Li's research, see one of his most recent publications: "Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion" ( https://www.nature.com/articles/s41422-018-0072-0 )
SHARE THE SCIENCE
Linheng Li, PhD
Investigator, Stowers Institute for Medical Research,
Affiliate Professor at the University of Kansas Medical Center,
and Co-Leader of Cancer Biology at the University of Kansas Cancer Center
"Uncover new strategies to manage hematopoietic diseases through HSC self-renewal"
Free webinar. Open to the public.
Thursday, June 18th - 2pm Eastern Time/11am Pacific Time
RECORDING NOW AVAILABLE
About the speaker
We wish to thank Dr. Linheng Li for volunteering his time to speak on
Share the Science and sharing his valuable insight
on RNA modification to promote self-renewal of HSCs,
resulting in HSC expansion.
We also wish to also thank our generous sponsor and partner for this event,
WellSky Health, who continue to support cord blood
education through our “Share the Science” series.
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