Save the Cord Foundation and WellSky are proud to welcome Dr. Alvaro Moreira from the University of Texas Health Science Center, as our featured speaker for our next edition of Share the Science on March 18th, 2020. Join us to hear Dr. Moreira present his research using intranasal delivery of human umbilical cord tissue stem cells to restore lung growth and development in an animal model of neonatal lung disease.
Share the Science is a free webinar series focused on the cord blood industry and the latest research in this field. As always, we invite both health professionals and the general public to join us for this unique online educational series. Learn more about this exciting educational series here.
Cord tissue has long been overlooked as a medical resource; however, it is a vital source of mesenchymal stem/stromal cells (MSCs). This birth by-product is typically thrown away. Should we be saving it? If so, how and why? Dr. Alvaro Moreira joins us on March 18th, 2020 to discuss his research in this area using cord tissue MSCs to potentially restore lung growth.
Bronchopulmonary dysplasia (BPD) is a devastating lung condition that develops in premature newborns exposed to prolonged mechanical ventilation and supplemental oxygen. Significant morbidity and mortality are associated with this costly disease and effective therapies are limited.
Mesenchymal stem/stromal cells are multipotent cells that can repair injured tissue by secreting paracrine factors known to restore the function and integrity of injured lung epithelium and endothelium. Most preclinical studies showing therapeutic efficacy of MSCs for BPD are administered either intratracheally or intravenously. The purpose of this study was to examine the feasibility and effectiveness of human cord tissue‐derived MSC administration given via the intranasal route. Human umbilical cord tissue MSCs were isolated, characterized, and given intranasally (500 000 cells per 20 μL) to a hyperoxia‐induced rat model of BPD. Lung alveolarization, vascularization, and pulmonary vascular remodeling were restored in animals receiving MSC treatment. Gene and protein analysis suggest the beneficial effects of MSCs were attributed, in part, to a concerted effort targeting angiogenesis, immunomodulation, wound healing, and cell survival.
These findings are clinically significant, as neonates who develop BPD have altered alveolar development, decreased pulmonary vascularization and chronic inflammation, all resulting in impaired tissue healing. Our study is the first to report the intranasal delivery of umbilical cord Wharton's jelly MSCs in experimental BPD is feasible, noninvasive, and an effective route that may bear clinical applicability.
Dr. Moreira will discuss:
SHARE THE SCIENCE
Alvaro G. Moreira, MD, MSc
Assistant Professor in the Department of Pediatrics,
Division of Neonatology at the University of Texas Health Science Center at San Antonio
"Intranasal delivery of human umbilical cord tissue stem cells
restores lung growth and development in an animal model of neonatal lung disease"
Free webinar. Open to the public.
Wednesday, March 18th - 2pm Eastern Time/11am Pacific Time
About the speaker
We wish to thank Dr. Moreira for volunteering his time to speak on
Share the Science and sharing his valuable insight on
cord tissue as a valuable source of MSCs,
as well as its tremendous potential in emerging cell therapies.
We also wish to also thank our generous sponsor and partner for this event,
WellSky Health, who continue to support cord blood
education through our “Share the Science” series.
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